Polymers play an indispensable role in drug delivery systems due to their several beneficial physicochemical properties including biocompatibility, adaptability and controlled release of the drug. These are essential in the field of nanomedicine for targeted drug delivery and various applications. Polymers that are used in nanotechnology might be biodegradable or nonbiodegradable and ideally be nontoxic and nonreactive, making them suitable for various therapeutics agents. Among these, marine polymers have created more attention in the domain of drug delivery because of their feasible characteristics. Eventhough the ocean has vast sources of all natural products of renewable origin, it has been remained largely unexplored in the field of drug development. Marine sources such as marine algae, marine bacteria, marine seaweed, and marine collagen offer promising opportunities. These polymers that are derived from marine have properties such as biocompatibility, sustainability, biodegradability, versatility, nontoxic, abundant, easily producible, and cheap which help to deliver various therapeutic molecules, tissue engineering and specialized targeted therapy. Some instances of marine polymers are chitin, ulvan, carrageenan, chitosan, fucoidan, hyaluronic acid, chondroitin sulfate, alginates as well as exopolysaccharides from marine bacteria and cyanobacteria. This chapter deals with the comprehensive overview of the polymers that can be obtained from marine as a novel source for drug delivery systems.