The advent of Mechanically Stabilized Earth (MSE) walls marks a profound improvement over the conventional retaining walls owing to its enhanced stability, versatility, and cost-effectiveness. The integration of reinforcing elements aids in stability enhancement due to the coupled interaction between the reinforcements and surrounding backfill geo-material. Despite the global escalation of MSE wall construction, complex loading scenarios, such as accumulation of pore water and seismicity, have attributed to MSE wall failures. In this study, stability of a 10-m-high MSE wall having a base width of 8.5 m, against base sliding mode of failure, has been assessed using Janbu’s limit equilibrium approach via SLOPE/W module under both static and pseudo-static loadings along with comparative assessments on the attained Factor of Safety (FoS). Parametric variations of unit weights and friction angles of both backfill and engineered soil have been accomplished with water table variations accounted at three different locations. The detailed stability assessment of MSE wall conveys thorough insights into numerous factors contributing to stability variations. Consequently, the acquired FoS against base sliding failure mode has been utilized to acquire empirical equations via multiple linear regression (MLR) for stability evaluation under different loading scenarios for the above-mentioned wall configuration. These empirical equations have been made dependent on friction angle and unit weight of both backfill and engineered soil, height of water table as well as loading conditions in case of seismic loading. The delineation of these predictive equation aids in the stability assessment against base sliding failure mode without undergoing further modeling studies for the accounted MSE wall configuration.