Multimodal analgesia is an integrated approach to pain management, combining various pharmacological and non-pharmacological techniques to target different pain pathways. This strategy aims to optimize pain control while reducing opioid use, accelerating recovery, and minimizing side effects. Key principles include the use of non-opioid analgesics, regional analgesia, and non-invasive therapies to provide synergistic effects that enhance pain relief. This chapter delves into the principles and strategies behind the evidence-based multimodal approach to perioperative analgesia, highlighting its benefits in commonly performed procedures and the medications and techniques involved. It emphasizes patient-specific approaches including preemptive analgesia, tailored drug regimens, and continuous nerve blocks for postoperative recovery. By combining multiple techniques, multimodal analgesia not only enhances the patient’s experience but also effectively addresses postoperative morbidity, healthcare costs, and the opioid epidemic.