Preventing or minimizing central nervous system sensitivity and sensory disruptions during surgery, extending the duration of pain relief, and minimizing the use of analgesics are the best ways to manage postoperative pain. Taking effective measures to relieve pain in advance and reduce the pain sensitivity of central and peripheral nerves before harmful stimulation by surgery can accelerate the recovery of patients and significantly reduce the patient’s surgical trauma and postoperative pain compared with analgesia given after the start of pain. The intervention of central neuraxial sensitization and peripheral sensitization to stop the spread of pain and achieve postoperative pain relief is known as preemptive analgesia (PA). PA has emerged as a popular therapeutic approach for anesthesiologists treating postoperative patient-controlled analgesia. Clinical guidelines for advanced analgesia are still missing, though.