This work defines degenerate extended Changhee–Genocchi polynomials of the second kind and analyzes some properties of them. Also, several relations and applications covering recurrence relations, addition formulas, implicit summation formulas, and correlations with previous polynomials in the literature are provided. Furthermore, higher-order degenerate extended Changhee–Genocchi polynomials of the second kind are derived and numerous new relationships and properties are investigated.