This chapter delves into the ethical and security aspects of Sustainable Enterprise Resource Planning (S-ERP) within the context of Industry 4.0. S-ERP integrates sustainability into enterprise resource planning, which is essential for businesses operating in a technology-driven environment characterized by advanced technologies such as IoT, AI, and big data analytics. The chapter emphasizes the critical importance of incorporating ethical principles and robust security measures into S-ERP systems to address the challenges posed by these technologies. The discussion highlights how traditional ERP systems differ from S-ERP, particularly in integrating sustainability principles that encompass environmental, social, and economic dimensions. The ethical concerns surrounding S-ERP are explored through various frameworks, including utilitarianism, deontological ethics, and virtue ethics, emphasizing the responsible use of AI and data analytics, ensuring transparency, and mitigating biases. The chapter also underscores the complexities of cybersecurity within S-ERP, given the interconnectedness of systems and the sensitive nature of data managed by these platforms. It explores the necessity of advanced cybersecurity protocols, such as multi-factor authentication, encryption, and real-time threat detection, to protect against cyber threats. Moreover, it discusses the ethical challenges posed by technologies like AI, machine learning, and computer vision in S-ERP. It proposes frameworks to address these challenges, such as transparency, cultural sensitivity, and continuous ethical training. By examining the ethical and security dimensions, the chapter provides a comprehensive understanding of the multifaceted challenges faced by organizations implementing S-ERP in Industry 4.0. It advocates for a holistic approach to ensure that these systems not only drive operational efficiency and sustainability but also adhere to high ethical standards and resilience in the face of evolving technological challenges.