The chapter on structural heart interventions covers common procedures such as transcatheter aortic valve implantation (TAVI), mitraclip, atrial septal defect (ASD) closure, percutaneous transluminal mitral commissurotomy (PTMC), left atrial appendage (LAA) closure, paravalvular leak closure, and many more. The section will feature real clinical cases with emphasis on the clinical indication, procedure steps, cardiac imaging, and haemodynamics. The discussion will involve highlight the evolving techniques and current technologies in percutaneous treatment of patient with structural heart abnormalities.