Predicting the mechanical strength of 2 × 2 twill weave fabrics and inter-yarn hybrid twill weave fabric composites reinforced with natural fibres is the main goal of this research since it is essential for both manufacturing and practical applications. To achieve this, the study utilizes TexGen for geometric modelling and ABAQUS for Finite Element Analysis (FEA) to model and forecast the mechanical behaviour of hybrid natural fibre composites with polypropylene (PP) matrix under compression; the model offers a cost-effective alternative to costly experimental setups. A detailed Finite Element (FE) model of a 2 × 2 twill-woven fabric unit cell is created and analysed for various natural fibres, including flax, basalt, and jute, as well as their hybrid combinations. The study shows that the FE model reliably predicts the mechanical performance of woven textile fabrics, regardless of variations in material properties, geometric designs, and working conditions. Stress is mainly concentrated at yarn crossovers under uniform compression, impacting the fabric’s load-bearing capacity. Additionally, twill weave patterns distribute larger areas to bear external loads, resulting in broader warp-weft contact regions.