Amidst the rising demand for sustainable energy solutions in urban environments, reducing dependence on conventional sources is imperative. This study investigates the feasibility and benefits of integrating pico-hydro energy systems into the water supply infrastructure of high-rise buildings. The verticality of such structures provides significant water head, making them ideal for energy capture. The research extensively examines the potential for generating pico-hydro energy within these buildings’ water distribution systems. Pico-hydroelectric systems, characterized by compact turbines, are seamlessly incorporated into the water pipe network at regular intervals, tapping into the kinetic energy present during water distribution. The main objective is to evaluate power generation using a pico-hydro turbine within an experimental setup consists a pico-hydro turbine coupled with a DC generator, LEDs, water meter, nozzle, and water distribution system. Theoretical calculations are grounded in fundamental fluid mechanics equations, with validation through experimental and numerical analyses. Results provide valuable insights into pico-hydro energy generation’s potential as a sustainable solution for meeting high-rise buildings’ energy demands. Furthermore, this study aims to inform urban architects, planners, designers, and policymakers about integrating renewable energy technologies into urban infrastructure. Such integration could lead to more sustainable and resilient practices in urban environments. The findings suggest opportunities for optimizing pico-hydro systems to enhance efficiency and scalability. Additionally, exploring integration with smart grid technologies could enable seamless energy distribution and management in urban contexts. By embracing these insights, stakeholders can make informed decisions regarding the implementation of renewable energy solutions, contributing to a more sustainable urban future.