This book chapter provides a comprehensive exploration of zoonotic disease surveillance and monitoring in swine populations, emphasizing the critical intersection of human and animal health. It delves into the common zoonotic diseases prevalent in swine, their transmission patterns, clinical signs, and prevention strategies. It covers various surveillance methods, tools, challenges, and emphasizes the adoption of a One Health approach. It highlights the complexities and intricacies of establishing effective surveillance systems, emphasizing the need for data integration, implementation strategies, and institutional capacity building. The One Health approach is presented as a collaborative framework to enhance zoonotic disease surveillance, involving joint efforts across human, animal, and environmental health domains. It also addresses the challenges in monitoring and controlling zoonotic diseases in swine, proposing potential solutions aligned with the evolving landscape of infectious disease management. It emphasizes the need for sustained investment, coordinated efforts, and innovative approaches to establish and maintain effective zoonotic disease surveillance systems, ultimately safeguarding both animal and human health.