Some forecasts predict that conventional automotive fuels will run out in the next three to four decades. Furthermore, traditional fuel burning generates a substantial amount of gaseous and particulate pollutants. Because of these issues, the research community has to look for alternative solutions to conventional fuels. Alcohol-based fuels are the most extensively researched alternative fuel due to their numerous beneficial features that make them suited as an internal combustion engine fuel. These fuels are considered environmentally benign since they lower the quantity of hazardous gaseous, particulate, and greenhouse gas emissions. Additionally, blending these fuels with conventional fuels can extend the run-out period of conventional fuels. Methanol is among the most often utilized fuels in the alcohol family due to its several advantageous properties, including a high-octane number, high heat of vaporization, high flame speed, and a low stoichiometric air–fuel ratio, etc., making it a suitable alternative fuel for IC engines. Having a high oxygen-to-carbon and hydrogen to carbon ratio, methanol generally produces less amount of CO2, CO, HC, Soot, and smoke emissions. The emission of NOX depends upon the operating conditions and quantity of blending with conventional automotive fuels. The main challenge in the application of methanol as a fuel is the unregulated emissions such as unburned methanol, formaldehyde, benzene, toluene, soluble organic fraction, etc. Studies indicate that an equal blending ratio of methanol and gasoline lowers the HC, CO and NOX emissions between 30 and 40%. The blending of 10% methanol with diesel lowers the CO and THC emissions by 30 and 37%, respectively, but the NOX emission was increased by 23% as compared to diesel alone. With increasing the amount of methanol content in the fuel blend, the emissions of formaldehyde, unburned methanol, benzene, toluene, and soluble organic fraction also increase. However, the emissions of ethylene, 1,3-butadiene, isobutene, and propylene show a slight decrement. Xylene, acetaldehyde, and acetone emissions remain almost the same. This chapter includes an in-depth review of the regulated, unregulated, and particulate characteristics of methanol-powered engines.