Experimental rodent models have garnered widespread adoption in the ever-evolving landscape of modern biomedicine. The frequently utilized experimental rodent models are experimental mice and rats. Experimental mice, artificially bred from wild house mice (Mus musculus) via a directional selection approach, have been bred into more than 500 independent inbred and outbred strains. In Europe, experimental rats, directionally bred from wild Rattus norvegicus, were first harnessed for experimental purposes. Based on a burgeoning body of research, researchers become increasingly proficient in understanding rodent liver anatomy [1]. Thanks to advancements in microsurgical techniques, experimental rodent models are increasingly utilized in liver-related research (e.g., liver regeneration, liver failure, liver transplantation, and liver tumor research) [2–4]. Given the role of the inflammatory response in ALPPS-induced liver regeneration [5], immunocompetent experimental rodents (e.g., BALB/c and C57BL mice, and Wistar, Spraque-Dawley, Lewis, and ACI rats) are typically employed in existing research.

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Experimental Model of ALPPS

  • Feiyu Chen

摘要

Experimental rodent models have garnered widespread adoption in the ever-evolving landscape of modern biomedicine. The frequently utilized experimental rodent models are experimental mice and rats. Experimental mice, artificially bred from wild house mice (Mus musculus) via a directional selection approach, have been bred into more than 500 independent inbred and outbred strains. In Europe, experimental rats, directionally bred from wild Rattus norvegicus, were first harnessed for experimental purposes. Based on a burgeoning body of research, researchers become increasingly proficient in understanding rodent liver anatomy [1]. Thanks to advancements in microsurgical techniques, experimental rodent models are increasingly utilized in liver-related research (e.g., liver regeneration, liver failure, liver transplantation, and liver tumor research) [2–4]. Given the role of the inflammatory response in ALPPS-induced liver regeneration [5], immunocompetent experimental rodents (e.g., BALB/c and C57BL mice, and Wistar, Spraque-Dawley, Lewis, and ACI rats) are typically employed in existing research.