ALPPS vs Traditional Two-Stage Hepatectomy
摘要
Liver resection has become an effective treatment for primary and secondary liver malignancies. Clinical practices validate that patients eligible for liver resection can often achieve the best radical treatment results. For patients without underlying liver diseases, the mortality rate after major liver resection is 3.2–7%. In contrast, for those with fibrotic livers, the postoperative mortality rate can be as high as 32% [1–3], mostly due to postoperative liver failure caused by insufficient future liver remnant (FLR) [4]. Safe liver resection depends on preserving sufficient FLR and ensuring adequate inflow, outflow, and bile drainage of the FLR parenchyma. Preoperative portal vein embolization (PVE) is a traditional and safe interventional procedure, embolizing the portal vein on the tumor-bearing side to redistribute intrahepatic blood flow, thereby promoting FLR hypertrophy. PVE improves the safety of extensive liver resection and reduces its mortality rate to 3.3% [5]. This technique induces FLR growth, providing 70–80% of patients with the opportunity for extensive hepatectomy [6, 7].