The raising of structure in the sloping part of Himalayan areas have motivated the researchers to consider the effect of soil slope-structure interaction (SSSI). The soil and slope condition can influence the seismic response of buildings through SSSI phenomenon. The interaction behavior of soil-structure in a slope has a critical impact on development of shear band due to strain localization and thus stability of slope. The main reason to study this behavior of strain accumulation in slope is due to tendency of progressive failure in slope mass under seismic condition. In this paper, effect of strain localization in slope have been carried using finite element (FE) simulation. The strain localization in soil slope have been analyzed with material modeling, boundaries, SSI effect, and magnification factor response for varying height of buildings on varying slopes. Three boundaries were implemented to study these parameters and maximum reduction of responses were found with infinite element boundary. The study recommend that, the mid-rise height of structure reduces amplification response with inclinations. The approach discussed in the study can be implemented to ensure risk reduction with sustainable infrastructure development under seismic performance.