The African Union’s (AU) Agenda 2063 envisions a prosperous Africa anchored on sustainable peace, with the “Silencing the Guns” initiative at its core. This paper examines South Africa’s efforts towards conflict prevention and peace building within this context, given its strategic position within the region. In post-apartheid period and with its Pan Africanist foreign policy, South Africa has participated in mediation and peacekeeping in Burundi, Sudan, and Democratic Republic of Congo (DRC). These interventions show understanding of AU goals of stabilization and governance reforms. However, its effectiveness is sometimes hampered by factors such as operational constraints, availability of resources, or domestic social, economic differences among others. By participating in African and UN intercessions, South Africa has shown its ability to deal with conflict and contribute to post conflict reconstruction. Nevertheless, there are still criticisms as regards the perceived hegemons and logistics, which should be addressed for a more effective and equitable goal. This paper calls for improved cooperation among the regional bodies, capacity development of institutions, and people to people interventions for conflict prevention. The study notes that South Africa is a critical actor in supporting the “Silencing the Guns: Demobilizing Conflict, Consolidating Peace” initiative, but durable peace in Africa is possible only with the elimination of systematic obstacles and balanced cooperation between national and supranational actors.