The Hajj pilgrimage represents one of the largest mass gatherings globally, posing substantial challenges in terms of health and safety management. Millions of pilgrims converge each year in Saudi Arabia to fulfil their religious obligations, underscoring the critical need to address the various health risks that may emerge during such a large-scale event. Health volunteering plays a pivotal role in delivering timely and high-quality medical services to pilgrims. This study introduces the Integrated Health Volunteering (IHV) framework, designed to enhance health and safety outcomes through an optimised, rapid response system. The IHV framework facilitates the coordinated deployment of healthcare professionals—including doctors, anaesthetists, pharmacists and others—in critical medical emergencies such as cardiac arrest and severe haemorrhage. Central to this framework is the integration of advanced technologies, including Artificial Intelligence algorithms, to support health volunteers’ decision-making. The framework has been validated and subjected to accuracy assessments to ensure its efficacy in real-world situations, particularly in the context of mass gatherings like the Hajj.