Due to load variations and foundation disturbances, hydraulic buildings on self-weighting wet sinking loess foundations are vulnerable to uneven settlement, which compromises the project’s structural safety. Understanding the settlement and settlement characteristics of a group pile foundation supporting a pumping station outlet tower structure under different load distributions and different pile spacing arrangements for a wet-submerged loess foundation is essential for future research. To simulate and analyze the effects of load and group pile spacing variations on the settlement characteristics of wet sinking loess foundations, the finite element simulation software ABAQUS was used in this study to build numerical simulation models of group pile foundations with pile spacing of 1.2, 1.6, and 2.0 m under variable load conditions. The research results indicate a positive correlation between the soil settlement of collapsible loess foundations and the magnitude of load pressure. Under various pile spacing configurations, the center of the bearing plate is where the foundation’s maximum deformation settlement occurs, and 18 m below the surface is where the inflection point of the settlement change at the pile-soil contact region emerges. Uneven settlement will result in the distortion of the soil mass due to the pile group impact of the pile foundation. The foundation with 1.2 m pile spacing has the highest uneven settlement deformation, followed by 1.6 m pile spacing, and the settlement with 2.0 m pile spacing has the most consistent deformation. It is possible to analyze the uneven settlement of collapsible loess foundations and improve building design by using the research techniques and simulation results presented in this article as suggestions and references.