Self-healing materials are an innovative class of materials designed to autonomously repair damage, offering significant potential to enhance durability, reduce maintenance, and improve sustainability across various industries. This chapter delves into the key challenges and limitations hindering their widespread adoption, including high production costs, energy-intensive manufacturing, and scalability issues. Compatibility with existing industrial processes, material limitations such as mechanical performance and healing efficiency, and concerns regarding environmental sustainability and recyclability are critically examined. Additionally, the chapter addresses the importance of regulatory and safety standards to mitigate risks associated with novel self-healing components. Despite these challenges, ongoing research and technological advancements are paving the way for cost-effective, efficient, and environmentally sustainable solutions. By exploring these issues, this chapter highlights the interdisciplinary efforts needed to realize the full potential of self-healing materials, ensuring their safe and effective integration into industries like construction, automotive, and electronics.