The potential for Origami to enhance the development of spatial knowledge among children is generally recognised. However, limited knowledge exists regarding its effectiveness among individuals with blindness, as well as its inclusive or exclusive aspects within this unique demographic. This exploratory case study focuses on two individuals with blindness who demonstrate exceptional spatial knowledge and a strong affinity for origami. The study aims to deepen the understanding of origami's potential in enhancing spatial skills in individuals with blindness, while also exploring various physical aspects of origami that could increase accessibility for this population.