In the USA, heart disease continues to be the top cause of death, with significant differences in mortality rates among various demographic groups. This study aims to explore the influence of gender and ethnicity on heart disease mortality rates across various US states. Using heart disease mortality data for adults aged 35 and older, we investigate whether specific racial and ethnic groups are disproportionately affected and examine gender-based variations in mortality rates. Our findings reveal significant disparities, with American Indian, Alaskan Native, and Black populations experiencing the highest mortality rates. Additionally, males exhibited higher mortality rates than females across all states. These disparities underscore the need for targeted healthcare interventions and policies that address cardiovascular health inequities. By identifying at-risk populations, this study provides insights that can inform the development of cultural and gender-sensitive heart disease prevention and management strategies.