Toxic gases produced during a fire must be understood while assessing the fire threat. In reality, carbon monoxide poisoning brought on by inhaling the gas accounts for the majority of fire-related fatalities. Smoke is regarded as the greatest threat to human life in the event of unintentional building fires. Additionally, most countries’ building fire safety norms and regulations do not include smoke toxicity requirements. Commercial enterprises like chemical, nuclear, and thermal power plants have fuel placements inside enclosures elevated far above the floor. Additionally, the cabin position of the ship for storing marine diesel fuel is above the base, suggesting enhanced circumstances for a pool fire. From the fire safety perspective, assessing the toxicity of the gases produced under various pool fire circumstances inside the compartment is necessary. Therefore, this study investigates the effect of diesel pool fire in a full-scale compartment on different elevation levels. Full-scale compartment simulations were performed with 0.8 m diameter diesel fuel pans of varying heights in the central location. The analyzed parameters were the flame temperature, door temperature and smoke layer height. The effect of various crucial modeling Smagorinsky constants was studied on the elevated pool fires. Understanding the complexity of a large-scale test environment with changing combustion conditions both momentarily and geographically is crucial. Therefore, the Fire Dynamic Simulator software results were validated with the experiments, which agrees with the data. The results from the study are significantly valuable for understanding the behavior of hazardous gases in commercial enterprises, promoting disaster risk reduction in case of fire accidents.