Diseases associated with posterior segment of the eye like age-related maculopathy and diabetic retinopathy are prime reasons that extremely menace normal vision as well as healthy well-being, and their therapy is highly difficult for ophthalmologists, researchers, and specialists. Delivery of drugs for the treatment of posterior segment oculopathy using noninvasive procedures is the need of time; however, it is very challenging. Recently, several new topical systems have been formulated which are promising due to the improved patient compliance as the intervention of surgery or needles is negligible. This chapter primarily focuses on the different means of drug delivery for the therapy of conditions associated with the posterior segment of the eye. In the first part of this chapter, the anatomy of ocular posterior segment and the associated diseases are crisply discussed. Further, the biological ocular barriers that prevent the drug delivery are mentioned. Afterward, both invasive and noninvasive routes explored by the researchers for the therapy of posterior segment oculopathy are discussed. As a follow-up, new strategies in the delivery of therapeutics via the noninvasive route using different nanovehicles and contact lenses are extensively elaborated which also draws the conclusion that the potential of nanoformulations for the therapy of posterior oculopathy must be explored at the full extent with systematic and comprehensive efforts by researchers.