In the present scenario of climate change and food insecurity, it has become imperative to provide nutritive food to the growing population to meet dietary requirements for maintaining better physical and mental health. Agronomic crops like wheat, rice, and other cereals are insufficient to meet the entire food demand and alleviate hunger and malnutrition. Hence, horticultural edible crops in general and vegetables in particular provide lucrative opportunity to combat the food risk factor in sustainable agriculture. Vegetables are excellent source of minerals and vitamins in addition to fundamental food components. Nevertheless, the conventional production of vegetables in soils poses several threats such as disease and pest infestation and requires several tedious cultural operations like soil preparation, irrigation, weeding, plant protection measures, etc. to secure the ultimate quality crop of required quantity. Hydroponically grown vegetables offer viable answer to resolve these problems. Hydroponics facilitates production of manifold yields with high quality regardless of climate change, which is a burning issue adversely affecting growth and development pattern of crop plants. Different systems of hydroponics either nutrient water culture (nutrient film technique (NFT), deep water culture (DWC) and aeroponics), or substrate culture (use of coco peat, perlite, rockwool, etc.) can effectively contribute to improve water use efficiency with positive impact on vegetables production and availability. The future of food security is in hydroponics where the guaranteed supply of nutritive diet for every individual lies with superior quality and greater quantity of vegetables.