An ecological collection of commensal, symbiotic, and pathogenic microbes that live inside the human body is known as the gut microbiome. A complex pathophysiological disorder, metabolic syndrome (MetS) is associated with an increased risk of developing chronic non-communicable degenerative diseases (NCDDs) including cancers. Additionally, MetS linked to type 2 diabetes mellitus (T2DM), involved in etiopathogenesis of chronic kidney disease (CKD), cardiovascular disease (CVD), certain forms of insulin resistance, and other chronic inflammation. Its incidence is comparable to a worldwide epidemic. Recent research has linked gut microbiome dysbiosis—a disorder of dysregulated and disturbed intestinal bacterial homeostasis. Numerous studies indicate that the gut microbiota may have an impact on a number of MetS risk factors by disrupting the host’s metabolism. According to recent research, some metabolites generated by microorganisms, such as N,N-dimethylmethanamine oxide or trimethylamine N-oxide, Gram-negative bacteria’s lipoglycans or lipopolysaccharides (LPS), 1H-indol-3-yl hydrogen sulfate, and 4-Cresyl sulfate, might cause the subclinical inflammatory processes linked to MetS. Numerous variables, such as dietary nutrition, toxic lifestyle, and medicaments, alter the taxonomic species or quantity of the gut microbiota. Supplements categorized as prebiotics, bifidus such as fructo-oligosaccharides, probiotics microflora or supplements, synbiotics (well mixture of prebiotics and probiotics), or postbiotics, i.e., biogenics, metabiotics etc. are gaining popularity due to their potential effects on the metabolic syndrome and gut microbiota. This chapter’s primary goal is to draw attention to the relationship between alterations in gut microbial metabolites and various dietary approaches. Our primary emphasis is researching whether or if certain dietary patterns are effective in reducing inflammatory processes, such as leaky gut and the endotoxin’s inflammation (successive endotoxemia) or LPS-driven toxicity, a kind of sepsis. We also discuss the potential for probiotic dietary addendum to influence the immune regulatory system and reduce adverse effects linked to metabolic syndrome risk factors.