Parkinson’s is a long-term, worsening condition that impacts the nervous system and the body parts regulated by nerves. It is defined by rigidity, bradykinesia, postural instability, and various motor and non-motor symptoms. Symptoms start progressing gradually as they are not recognizable at a very early stage. There is no cure but medicine can reduce the symptoms to some extent. The symptoms of Parkinson’s are tremors, rigidity, difficulty in walking balance, and slow movement. The problem may also arise with cognition, behavior, sleep, and sensory system. Dementia is common in advanced stages. The currently available medicines manage to work effectively on motor symptoms but do not stop the disease’s progression. This chapter discusses the epidemiology, pathophysiology, improvement in its progression, therapeutic management, and recent discoveries of potential treatment associated with the diagnosis of Parkinson’s disease (PD).