The intensification of farming practices, urban expansion, and land use changes has led to increased pollution levels, and pose threat to global agricultural productivity and food security. However, with the advent of genetic and molecular approaches, the crop plant's resilience to contaminants can be improved. Formerly, for remediation of toxic pollutant from the soil, phytoremediation, and chemical amendment-based approaches were used due to cost-effectiveness, however, these methods have several limitations. Importantly biotechnology has transformed modern-day agricultural practices, crop breeding, and improvement. These biotechnological techniques involved innovations, such as genome editing, marker-assisted selection, and genomics-assisted breeding. Notably, transgenic techniques involve inserting and deleting specific gene even from distinct species used for genetic modification of plants to acquire new traits. Moreover, technologies, such as genome editing and DNA markers, also revolutionize plant breeding and can help improve crop productivity. This chapter highlights the potential application of genic, molecular approaches for improved crop stress resilience and productivity.