The integration of advanced technology into modern lifestyles has paved the way for research on highly reliable, non-invasive and easy-to-use wearable biosensors for continuous real-time health monitoring. Nanoparticle-based sensors can significantly increase the accuracy of diagnostic assays. Various nanomaterial types with distinct properties have been employed to create a range of biosensors. These nanosensors enable rapid and precise detection of various diseases, pollutants and contaminants, providing unique insights into human health and well-being. Continuous monitoring of biomarkers is valuable for diagnostics, facilitates disease prediction and helps users maintain a healthy lifestyle. This chapter highlights key findings on the use of nanomaterials in various wearable health monitoring sensors. Owing to their unique nanoscale properties, nanomaterials increase sensitivity and allow the detection of biomarkers and physiological parameters at low concentrations in body fluids. These devices facilitate remote patient monitoring by continuously tracking vital signs. Additionally, this chapter discusses recent breakthroughs in this field of wearable health devices and focusses primarily on devices that are useful for the regular monitoring of diagnostic biomarkers. The fabrication of nanosensors into ultrathin wearable materials can maintain accuracy and comfort, ensuring a seamless user experience. These materials can be integrated into fabrics, adhesive patches, or even directly onto the skin. Moreover, they permit long-term use without causing discomfort or irritation. A detailed discussion on the application of wearable nanosensors in human disease diagnostics is also included.