As artificial intelligence (AI) progressively transforms disability support, its importance in personalized assistive technology is growing markedly. AI-driven personalized support solutions mitigate the obstacles encountered by those with impairments, facilitating enhanced access to education, healthcare, and social engagement. The amalgamation of AI with personalized assistive technology has resulted in significant improvements, offering customized help that improves autonomy and quality of life. Innovations including virtual assistant chatbots, wearable gadgets, predictive analytics, and automated systems are revolutionizing disability support, enhancing its interactivity and responsiveness. This chapter examines the integration of AI-driven personalized assistive technologies, emphasizing significant applications including AI-enabled motion detection for improved accessibility and visual analysis for tailored support. Furthermore, it explores AI-driven personalized healthcare solutions, encompassing virtual assistant chatbots for patient assistance and education, telemonitoring via wearable devices, predictive disease analytics for customized therapy, and automated appointment scheduling. These developments not only improve accessibility but also establish a more cohesive and responsive support structure for those with impairments. Through the utilization of AI's capabilities, assistive technology is advancing, promoting a more inclusive society in which those with disabilities may navigate life with enhanced ease and autonomy.