Sleeping pills should not initially be used in the treatment of OSA patients with insomnia. The treatment of OSA itself should be prioritized. If insomnia is present despite the proper use of CPAP, we suggest the use of sleeping pills. Problems with the use of sleeping pills may include the aggravation OSA, for example, decreased respiratory events due to decreased upper airway hypotonia and decreased ventilatory response, along with prolonged respiratory event time. It has been reported that orexin receptor antagonists can mildly suppress a decrease in average SpO2, but as they are new drugs, there are still not many reports on them.