Women are globally acclaimed as worthy entrepreneurs but in context to several developing nations like India, they are less engrossed in entrepreneurial ventures. In India, less number of women possesses entrepreneurial orientation and as a result, this distends the challenge of development through sustainability. Personality factors significantly impact women orientation towards entrepreneurship. The measurement of such factors can be done using different personality dimensions like “openness, conscientiousness, extraversion, agreeableness and neuroticism.” The objective of present article is to identification of big five traits of personality as well as their impact in promoting entrepreneurial orientation among Indian women. Therefore, after an (SLR), i.e., systematic literature review, 13 crucial personality dimensions are identified and extracted. Further, a field enquiry and investigation including brainstorming sessions as well interview sessions with different experts in industry resulted in five dimensions of personality, finally. Total 22 experts participated in interview as well as brainstorming session. In order to find out the hierarchical interaction between dimensions, an Interpretive Structure Modeling (ISM) has been used in the present research. To identify driving personality dimensions of women entrepreneurs in India, Fuzzy MICMAC approach has also been employed in this research. The findings suggest that five dimensions, (OCEAN) play a very important role in creating entrepreneurial orientation among women. The outcomes of the study can help the government, policymakers, and academic institutions effective policy management and development of an entrepreneurial arena which can facilitate in creation of more women entrepreneurs in an economy.