Meta-Health is a paradigm shift in healthcare, which embraces big data, digital technologies, and the idea of interconnection to bring improvements to patient care and its corresponding outcomes. However, integration and analysis of vast amounts of sensitive health information create significant demands and challenges in assuring data privacy and security. Specifically, this chapter will elaborate on challenges of data privacy and security in Meta-Health, focusing on major concerns and threats and regulatory requirements that shape the landscape; the current study of the leading issues includes data privacy principles and standards, security frameworks, risk management strategies, and emerging technologies such as AI, blockchain, and IoT that are driving Meta-Health data security. This chapter also talks about ethical considerations and the dynamic regulatory environment to provide a view on best practices toward patient data protection while allowing access to such data. By considering the right attention paid to these critical areas, the chapter offers professionals in the healthcare field, data scientists, and policymakers the foundation of a broad-based understanding of the strategies for Meta-Health that will further patiently trust and enable the use of health data in a secure manner in this digital era.