Early childhood intervention programs for young children with diverse disabilities (birth to 6) have been proven effective in enhancing children’s development. The design of these programs varies with contextual, regional, and cultural differences, including policy, extant educational systems, resources, family roles and expectations, and availability and expertise of professionals. This chapter explores important concepts and guiding principles of early childhood intervention, highlighting the use of evidence-based practices within a family systems framework, taking into account cultural responsiveness and underscoring the uniqueness of each family unit. We also discuss competencies needed by the professionals providing early childhood intervention, such as collaboration, fostering communication between families and professionals, and conducting authentic, culturally sensitive, and strengths-based assessment of children and families. The chapter also identifies challenges and considerations in the design of effective intervention programs that are contextually relevant for children and families who live in lower and middle income countries.