In an era in which the prevalence of smartphones and their associated applications has skyrocketed, it is relevant to explore the applications of these devices to promote public health, specifically, smoking cessation. The main objective of this study was to determine which smoking cessation applications have been developed considering empirical evidence. In relation to the applications tested or evaluated, in the systematic review carried out it was observed that one of the techniques that offers the best results is acceptance and commitment therapy (ACT). Likewise, it was observed that those applications that were not based on a solid technique did not show such favorable results. It is important to note that most of the tested applications with published results were not available in the application stores. The results of the present study shed light on the applications tested and evaluated and are consistent with those of meta-analyses and reviews carried out by other authors.