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Thrombotic thrombocytopenic purpura (TTP) and hemophagocytic lymphohistiocytosis (HLH) are both rare hematological conditions, occurring due to pathological immune dysregulation, and are associated with high mortality. They both occur due to overlapping trigger factors; however, they do not coexist usually. The diagnosis is often challenging and delayed due to the rarity of the disease, thus worsening the prognosis.

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TTP/HUS and HLH Syndromes

  • 章节

  • 发表日期：

    2025年

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  • Gunjan Chanchalani,
  • Seema Tekwani,
  • Vivek Dave

摘要

Thrombotic thrombocytopenic purpura (TTP) and hemophagocytic lymphohistiocytosis (HLH) are both rare hematological conditions, occurring due to pathological immune dysregulation, and are associated with high mortality. They both occur due to overlapping trigger factors; however, they do not coexist usually. The diagnosis is often challenging and delayed due to the rarity of the disease, thus worsening the prognosis.