A 45-year-old male patient presented to the emergency department with abdominal pain and vomiting. On evaluation, he was found to have a pancreatic tumor and subsequently underwent a Whipple procedure. He was doing well till the fifth postoperative day when he developed oozing blood from the surgical site, hemorrhagic collection in the drain associated with a drop in hemoglobin, and hypovolemic shock. So he was reexplored and found to leak at the pancreas jejunum junction, which was corrected and shifted to ICU for respiratory and hemodynamic support. The arterial line and central line in the internal jugular vein were inserted intraoperatively. He was started on TPN and fluid management. Vasopressor support was weaned off gradually. On the seventh POD from reexploration, he developed febrile spikes of 101 F; hence, he was worked up for nosocomial infection. His chest X-ray didn’t show any infiltrates, the surgical site was clean, and the Foley catheter was revised. Blood cultures were sent with 1 set from the periphery.