Management of infections in immunocompromised patients is challenging, as untreated infections in these individuals can spread rapidly and lead to fatal outcomes. Given the complexity of the immune system, it is remarkable that it functions so effectively under most circumstances, rather than failing frequently. However, when it does fail, pathogens can proliferate unchecked, presenting significant clinical challenges. Diagnosing infections in these cases is difficult because immunosuppression disrupts the inflammatory and immune responses, which are essential for detecting and investigating infections.