A 45-year-old non-alcoholic male patient presented with severe continuous upper abdominal pain for 1 day, associated with vomiting and mild abdominal distension. He had a history of right upper abdominal pain 6 months back. His vital signs were stable. Abdomen examination showed mild tenderness and distension. Bowel sounds were sluggish. Investigations showed leukocytosis (13,000), elevated serum bilirubin of 2.5 mg/dl, and a fourfold increase in transaminases. Serum amylase was 1420 IU, and serum lipase was 1200 IU. Ultrasonography of the abdomen showed 7-mm gallstones, normal common bile duct (CBD), and bulky pancreas with peri-pancreatic fluid collection. He was diagnosed with acute pancreatitis, possibly of biliary etiology.