Vaccine safety and discernibility are basic parts of general well-being, particularly in a worldwide setting where antibody dispersion is complicated and includes various partners. Conventional concentrated frameworks for overseeing antibody supply affixes are inclined to failures, blunders, and purposeful acts of neglect, for example, record altering and immunization termination extortion. To resolve these issues, this paper proposes an incorporated structure that joins blockchain innovation with machine learning (ML) to guarantee the uprightness, straightforwardness, and security of immunization supply chains. The blockchain part gives a decentralized record that records each exchange and guarantees information changelessness, while Smart Contracts computerize consistency and identify peculiarities. The ML part upgrades the framework by giving prescient investigation to immunization interest, assessing the believability of antibody providers, and giving customized vaccination suggestions. Exploratory outcomes show that the proposed framework further develops immunization security by lessening the gamble of lapsed antibodies arriving at purchasers by 85% and upgrades detectability with a 92% accuracy rate in recognizing altered records. The system likewise accomplishes a 15% decrease in immunization squandering through exact interest determining. This study shows the capability of incorporating blockchain and ML innovations to make a hearty, effective, and secure immunization production network the board framework.