This chapter delves into the largest breakthroughs in techniques aimed at boosting the bioavailabilityBioavailability (enhanced) of vitamins and mineralsMinerals with a special focus on nanotechnology. Bioavailability is crucial for the effective absorptionAbsorption and utilization of nutrients and cutting strategies have been developed to tackle challenges, like low solubility, stability issues, and poor nutrient bioavailability. Innovative methods such as nanoencapsulation, liposomal carriers, solid lipid nanoparticles, supercritical fluid processes, and no Embulsions have been thoroughly explored. These approaches not only enhance nutrient solubility but also protect them from physiological degradation and environmental ensuring pre-size and controlled delivery within this bodyBody. Nanoencapsulation and lysosomal Systems use Nanoscale careers to safeguard nutrients like vitamins A, and, E from oxidative, and enzymatic breakdown. Meanwhile, solid–liquid Nanoparticles improve stability and enable the sustained release of delicate nutrients supercritical fluid Technology offers an eco-friendly way to produce fine particles with superior absorptionAbsorption characteristics. Nano emulsions with their Ultrafine droplets significantly boost the solubility and uptake of lipophilic vitamins. These nanotechnological innovations greatly benefitBenefits the developmentDevelopment of functional food and nutraceuticals promoting better healthHealth outcomes and effectively addressing nutrient efficiencyEfficiency. This chapter highlights the transformative potential of Nanotechnology in enhancing nutrient bioavailabilityBioavailability (enhanced) paving the way for innovative efficient and sustainable nutrition solutions.