This chapter explores and extends the concept of ‘gray zones’ in Latin American science and technology studies (STS), focusing on the production of technologies and knowledge in non-traditional spaces that are often considered informal or illegal. The authors argue for a more nuanced sociological approach that moves beyond rigid dichotomies of legality and illegality, and examines these gray zones as complex networks in which criminal, informal, and illegal activities intersect with those that are considered legal and licit. The chapter argues for the existence and space of gray in Latin American STS approaches, drawing on a variety of approaches from both Latin American authors and existing geographical, political, anthropological, and STS literature. The authors argue for a view that transcends the limitations of state-centered approaches and case studies in traditional settings prevalent in STS. Drawing on empirical studies of the drug war and counterguerrilla warfare in Colombia, the study proposes a set of interrelated questions key to understanding knowledge and technology production in gray areas.