The cyber-physical coupling in VPPs also brings new opportunities, particularly with the growing integration of networked facilities such as data centers and communication base stations, which have become significant participants in VPPs. For such loads, their reliance on cyber networks must be carefully considered during regulation. This chapter uses data centers as an example to explore how VPPs should adjust their operational strategies to accommodate these novel information equipment loads. This study focuses on multi-region Internet Data Centers (IDCs) managed by an Internet Service Company (ISC) aggregated as a controllable load. Spatial load regulation of online workloads is particularly considered to enhance load flexibility. A two-step workload scheduling mechanism is proposed, supported by a computation-power coupling model for ISCs. To overcome the challenges in solving the model under the assumption of workload scheduling homogeneity, a model reconstruction method is introduced, along with an efficient iterative algorithm for solution optimization. Experimental cases are designed to verify the effectiveness of the model and algorithm.