Resonance acoustic mixing is a new type of mixing process that can quickly transport and mix granular matter. However, there is currently a lack of research on the scale-up rules of its process. In addition, the simulation cost is a constraint on numerical simulation research. This study is based on the discrete element method to simulate the motion of mixed particles in resonance acoustic mixing, investigate the trend and law of motion during the scale-up process, and investigate the effect of particle stiffness reduction on the particle flow to reduce simulation time. The results indicate that when the container volume increases from 2L to 100L, the convective behavior throughout the entire granular bed still exists. Still, the intensity of convection gradually weakens due to the weaker driving effect growth compared to the driven substance's growth. Meanwhile, reducing Young's modulus of particles by three orders of magnitude does not cause significant changes in the convective flow field but can significantly shorten simulation time.