Skin cancer incorporates melanoma, basal cell carcinoma (BCB), and squamous cell carcinoma (SCC), which is the most prevalent cancer in the world affecting a large population and exhibiting increasing incidence rates. As observed, there remain gaps in skin cancer including; risk assessment of the affected population, the pathogenesis of the disease progression and management of the advanced stages of the disease. Today’s TNM staging, for example, carried out by AJCC, does not ignore tumor thickness or metastatic–affected lymph nodes, but has its drawbacks in the assessment of the outcome. Melanoma molecular diagnoses and therapies have improved survival, while BCC and SCC have not been improved by diagnostics and targeted therapies. This review discusses the types of skin cancer, the associated risk factors, classification, and the stage, together with recent advances in diagnostics, immunotherapy, and personalized treatments in order to establish knowledge deficit and future trends in this field of cancer control.