The oil and gas fields in Qaidam Basin are complex and multi-type, and the fracturing operation is complicated occasionally in the early stage of exploration. Some of the fracture pressure is higher than the predicted pressure, and it is difficult to start the fracture and add sand. The analysis of complex construction conditions is helpful to further understand the reservoir and master the reservoir conditions, so as to further guide the fracturing design of subsequent Wells in the same zone. To solve the problem of complex conditions in measure Wells, rock mechanical compressibility evaluation can be carried out first, and then based on construction second point data, net pressure fitting, G function and pressure drop process can be used to analyze the causes of complex conditions and put forward solutions. In the later stage of fracturing optimization, it is necessary to predict the formation construction pressure by combining the inversion of rock mechanics parameters. In view of the construction difficulties, the construction measures of wellhead pressure reduction are adopted to optimize the construction parameters, strengthen the liquid properties, and improve the construction success rate.