The Maokou Formation reservoirs in the Sichuan Basin is generally characterized by cross-development of cloud-lime interaction, and the reservoir is highly heterogeneous, and significant differences in acid rock reaction rates between dolomite and limestone at the high temperature, resulting in different lengths of fractures formed by acid fluids under different rock types. It is difficult to uniformly transform and the transformation process is poorly targeted. In order to further improve the production capacity of single well and optimize the transformation effect of these reservoirs, this paper conducts indoor large-scale physical model experiments to simulate the acid fracturing pressure process of reservoirs with different interaction modes of dolomite under geological conditions, and explores the transformation process and parameters for different types of heterogeneous reservoirs. According to the experimental results, it can be concluded that concentrated perforation in the cloud rock section is more conducive to modifying the extension of cracks in the dolomite section compared to in the limestone section; Compared with slick water as a pre fluid, self-generated acid significantly reduces the fracturing pressure of the reservoir and can effectively improve the transformation effect. Regardless of the cloud ash interaction mode, the alternating injection of acid fracturing technology is more complex than the single injection of acid fracturing. When the alternating injection level reaches three levels, the complexity of the fractures reaches its maximum. Continuing to increase the level, the complexity increases slowly. In summary, this paper has selected targeted transformation processes for different cloud ash interaction modes of reservoirs. The acid fracturing transformation process of self-generated acid and slow-release acid can effectively improve single well production by adopting centralized perforation in the cloud rock section. Through on-site testing, the single well production has achieved a breakthrough, setting a record for horizontal well production in the region.