Aiming at the serious sand problem during drilling and oil recovery in Gasi oilfield due to the loose reservoir cementation, poor reservoir lithology, and serious sand problem, based on the curing mechanism of organosilicone resin, we optimised the optimal ratio of curing agent, coupling agent, and softening agent, and successfully developed an organosilicone nano-resin high-efficiency sand fixing agent with low-temperature curing and good fluidity. The principle method of sand fixation is to inject the sand fixer into the sandy oil and gas layer, along with the water infiltration into the micropores of the rock, the particles are automatically adsorbed and gathered on the surface of the stratum sand, and a very thin particle aggregation network is formed by curing, which improves the strength of the rock, and thus achieves the purpose of sand prevention. The indoor study took the compressive strength and permeability of the rock core after sand consolidation as reference indexes, and also explored the influence of polymer adsorption, gel morphology and other factors on the consolidation strength. The experiments showed that the optimal formulation of the cementation system was 10% resin + 10% hardener + 8% coupling agent + 5% softener, and the compressive strength of the cemented core obtained after 72 h of curing at 60℃ in a constant temperature oven was 6.1 MPa, and the retention rate of permeability was more than 80%, which showed that the strength of the cementation was high and the permeability was maintained well. The field application was carried out in 10 wells in Gasi oil field, and the validity period was up to 300 days, which was good enough to be promoted.