In view of the fluid properties of high-salt reservoirs in Qinghai Oilfield and the need for enhanced oil recovery technology, this paper has carried out research and development of salt-tolerant surfactants and reservoir adaptability research. Through the compatibility, emulsification and interfacial tension of 24 kinds of single agents of three kinds of surfactants with the three reservoirs of Gasi, Gasi deep layer and Huatugou in Qinghai Oilfield, the surfactants used for the compounding of surfactants in Qinghai Oilfield were optimized. The results show that the compounded surfactants have the characteristics of low interfacial tension, strong anti-adsorption ability and high oil displacement efficiency, and have good adaptability to the target reservoir. When the product concentration is 0.1–0.3%, the interfacial tension can reach the order of magnitude of 10−2 mN/m. The water separation rate of emulsion formed by 0.3% surfactant and formation crude oil is less than 60% after 1 h.6 well groups have been implemented in Gasi N1-N21 reservoir, with a cumulative injection of 12,908 cubic meters of self-developed composite oil displacement surfactant. The cumulative oil increase is 3481.9tons, the water cut is reduced from 74 to 65%, and the monthly decline is reduced from 3.2 to 0.1%. This study provides a surfactant flooding system with strong adaptability and small damage for the development of high-salt reservoirs in Qinghai Oilfield, and could provide theoretical and practical support for the further innovation and promotion of this technology.