The tight oil reservoir of X oilfield is basically developed by oil well fracturing. In the process of water drive development, the oil well will flood quickly after water discovery, resulting in a low recovery degree (only 15.29%). The permeability of tight oil reservoir in X oilfield is low and the reservoir temperature is high, reaching 110 °C. Higher requirements are put forward for sealing and channeling pharmaceutical system. The analysis of influencing factors of tight oil reservoir channeling has not been carried out in X oilfield, and the existing channeling agent system cannot meet the requirements of tight oil reservoir channeling. Therefore, it is very important to study the key influencing factors and management methods of tight oil reservoir cross-flow. In this paper, taking tight oil in X oilfield as an example, a simplified theoretical model of viscous finger is established. The results show that the permeability of the reservoir is positively correlated with the degree of cross-flow. On the basis of theoretical model research, laboratory tests are carried out to further discuss the effects of permeability, fracture and permeability level difference on cross-flow. The results show that permeability, fracture and cross-flow degree are positively correlated. In the case of low permeability, the fracture is the main factor of channeling flow, and the greater the permeability stage difference, the greater the pressure difference to effectively start the low permeability layer. It can be seen that by increasing the viscosity of injected liquid and plugging the flow channel, the channeling can be effectively inhibited and the development effect of tight oil reservoir can be improved. Well group A of X oilfield was selected for deep profile control, and the average injection pressure per well increased by 10 MPa after profile control by selecting the formulation suitable for tight oil reservoir, effectively blocking the dominant channel, adjusting the injection profile, and achieving a good oil increase effect. This study has important guiding significance for the effective development of similar tight oil reservoirs.