This chapter investigates the spatial-temporal cooperative guidance problem for multiple flight vehicles without relying on time-to-go information. First, a two-stage cooperative guidance strategy is developed to realize the spatial-temporal constraints in two dimensions. This guidance strategy consists of two stages: cooperative guidance and PNG stages. To further extend the results to three dimensions, a planar pursuit guidance stage is additionally imposed at the beginning of guidance. Due to the independence of time-to-go estimation, the proposed guidance strategy possesses great performance in satisfying complex spatial-temporal constraints even under flight speed variation.