The widespread use of electronic cigarettes (e-cigs) has raised significant public health concerns, particularly with the increasing number of poisoning cases among children and adolescents. This chapter offers an overview of epidemiology, clinical manifestations, and mitigation strategies related to e-cig poisoning and injuries. The prevalence and epidemiology section delves into the high number of e-cig poisoning cases as a result of accidental ingestion and exposure to e-liquids. Geographical variations in e-cig use and poisoning incidents are discussed, underscoring the global nature of the issue. Clinical manifestations of e-cig poisoning are detailed, including the range of symptoms from gastrointestinal disturbances to severe neurological effects attributed to nicotine toxicity. The risks of substance abuse and injuries caused by explosions are discussed to emphasize the need for stringent regulation and monitoring of e-cig devices. The chapter concludes with a discussion on mitigation strategies that focus on regulatory measures, public health interventions, and research efforts to reduce the incidence of e-cig poisoning and injuries. Collaborative efforts across various sectors are needed to effectively address this emerging public health challenge.